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Additionally, blocking sialylation with pharmacological agents like ambroxol sensitizes the tumor to immune checkpoint blockade (ICB) therapies, such as anti-PD-1 and anti-CTLA4, significantly improving tumor control and extending survival in preclinical models

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doi:10.1016/j.ajog.2019.02.004

Gandhi goes on to say that while the high rate of mortality may be related to the severity of illness and underlying risk, it may also be due to chance because of the small number of participants, and that a larger, more definitive study of this drug may be warranted